Mirtazapine decreased the indomethacininduced ulcers significantly at all doses used. This study investigated the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of spondias mombin and ficus exasperata against indomethacininduced gastric ulcer in rats. Aug 15, 2010 accordingly, the aim of this study was to investigate the gastroprotective effect of rutin against indomethacin. Effect of hydrotalcite on indometacininduced gastric injury.
Osifo 2 department of health promotion and education, faculty of public health, university of ibadan, ibadan, nigeria. The leaves were extracted with methanol and antiulcer activity was. Medicinalherbal extracts containing phytoconstituents have significant anti ulcer activities in in vivo experiments on animal models, compared to reference drugs. Protective effects of naringin in indomethacininduced gastric ulcer in rats sengul emin 1, and gelen volkan 2 1 ataturk university veterinary faculty, department of physiology, erzurum, turkey. Selim department of biochemistry, faculty of pharmacy, tanta university, tanta, elgharbia, egypt abstract gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. In this regard, an animal model experiment was carriedout to determine the ulcerdose of indomethacin on female wistar rats. The present study explored the protective effect of paeonol at two dose levels in indomethacin indinduced gastric ulcer in rats. Antiulcerogenic activity of hydromethanolic extract of. Based on this objective, three varying doses 30, 40 and 50mgkgbw of indomethacin were respectively given orally to. Gastroprotective effect of vanillin on indomethacininduced gastric ulcer in rats. Quercetin attenuates, indomethacininduced acute gastric.
Nebivolol prevents indomethacininduced gastric ulcer in rats. Mitigating effect of avicenna marina on indomethacin. Considering the beneficial properties of this plant, we tried to examine the antiulcerative effects of z. The aim of this study is to investigate the protective effect of ozone therapy in an experimental rat model of acute gastric ulcer induced by indomethacin. Cat and gst activity in rat stomach thereby inducing gas. This corroborated with the findings of earlier studies who observed that high concentration of indomethacin in the blood resulted in uncoupling of endothelial cell dna. Protective effect of vitamin e on indomethacin induced. Effect of feronia elephantum corr fruit pulp extract on. Mitigating effect of avicenna marina on indomethacin induced. Hydrotalcite plays an important role in the therapy of gastric ulcer induced by nonsteroidal antiinflammatory drugs nsaids, but little is known about the mechanism. The effects of agomelatine on indomethacininduced gastric injury were investigated. Indomethacin induced crohns in rats bolder biopath. Accordingly, the aim of this study was to investigate the gastroprotective effect of rutin against indomethacin.
Recently, an alternative disease treatment approach is the research of medicaments from traditional medicine. May 25, 2018 effect of thyroid hormones on the healing of indomethacin induced gastric ulcers at days 3 a, c and e and 7 b, d and f after ulcer induction. Pdf indomethacininduced gastric ulceration in rats. Effect of hydrotalcite on indometacininduced gastric. The fruit pulp was extracted with ethanol and the antiulcer activity of the extract in indomethacininduced gastric ulceration in swiss albino rats was evaluated. Glycomacropeptide ameliorates indomethacin induced. Ranitidine at a dose of 150 mgkg reduced the mean ulcer area to 2. Our results clearly suggest that ulcer induced by oral exposure of rats to indomethacin as demonstrated by significant increases in volume of gastric juice, pepsin activity, free and total acidity as previously reported by 25,26 who noted the relationship between acid production, ph, volume of gastric juice and pepsin activity, could be. Nov 26, 2008 the antiulcer activities of 15, 30, and 60 mgkg mirtazapine have been investigated on indomethacininduced ulcers in rats, and the results have been compared with that of the control group. Full length article mitigating effect of avicenna marina on indomethacin induced gastric ulcer in male albino rats magda m.
Antiulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats adewoye e. Dexmedetomidine was administered intraperitoneally at 10, 25, 50 and 100 gkg dosages in distilled water to groups of rats fasted for 24 h. Indomethacin has previously been reported to decrease antioxidant enzymes sod, cat, and. Diabetes was induced in rats by a single dose of streptozotocin stz followed by gastric ulceration using indomethacin, and melatonins action was studied by its application prior to indomethacin exposure.
Request pdf gastroprotective effect of garlic in indomethacin induced gastric ulcer in rats objective. Request pdf quercetin attenuates, indomethacininduced acute gastric ulcer in rats abstract peptic ulcer diseases are common and are induced by many factors, including stress, smoking, and. The antiulcer activity of hydromethanolic extract of andrographis culata ape was investigated using 36 rats. Three groups received indomethacin 30 mgkg body weight orally by orogastric gavage on two consecutive days.
The present study aimed to explore the possible effect of quercetin on acute gastric ulcer induced by indomethacin in rats. An acetic acid ulcer induced in the rat stomach is a. The parameters assessed were ph and acid concentration of. Gastroprotective effect of garlic in indomethacin induced gastric. Research article the protective effect of testosterone on indomethacin induced gastric ulcer in female sprague dawley rats u. Usnea longissima, a medicinal lichen of anatolia turkey, is used in the treatment of gastric ulcer in local folk medicine. Lizhong decoction lzd, a wellknown traditional chinese medicine tcm formula, is commonly prescribed for treatment of gastrointestinal diseases. Upregulation of collagenase1 and 3 in indomethacininduced gastric ulcer in diabetic rats.
Umaru ij 1, 2 and umaru ha 3 1 faculty of resource science and technology, university of malaysia sarawak, kuching, kota samarahan, malaysia 2 department of biochemistry, federal university wukari, taraba, nigeria. Gastroprotective effect of rutin against indomethacin. Plants with antioxidant capabilities are used as herbal treatments for ulcer diseases. In another study, indomethacin 50 mgikg was injected twice a day and the animals were killed after 3 days. Gastroprotective and antioxidant effects of usnic acid on. Test for effects of dexmedetomidine on indomethacininduced ulcers in rats we investigated the antiulcerative effect of dexmedetomidine using an indomethacininduced ulcer model in rats 18. Ulceration was induced by a single oral administration of indomethacin 30 mgkg body weight. The antiulcer activities of 15, 30, and 60 mgkg mirtazapine have been investigated on indomethacininduced ulcers in rats, and the results have been compared with that of the control group. Agomelatine prevents indomethacininduced gastric ulcer in rats. Ulceration was induced by a single oral administration of indomethacin 30mgkg body weight b. The pretreatment were continued for 14 days, at the end of the 14th day, rats from group two to group 6 were kept fasting for 24 hrs and indomethacin were administered orally.
Ulcerated rats were orally administered with esomeprazole a reference drug at a dose of 20mgkg body weight, and spondias mombin and ficus. Color of gastric mucosa changed from greyish pink to reddish pink in group given indomethacin. Jan 21, 2020 lizhong decoction lzd, a wellknown traditional chinese medicine tcm formula, is commonly prescribed for treatment of gastrointestinal diseases. In this study, a total of 5 groups were created as the sham, ulcer, omeprazole, agomelatine 1 mgkg and agomelatine 5 mgkg groups. This study investigated the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of spondias mombin and ficus exasperata against indomethacin induced gastric ulcer in rats. The rats received famotidine 50 mgkg body weight, quercetin 50 mgkg body weight, or vehi cle alone for 15 consecutive days by oral gavage. Antiulcerogenic mechanism of magnesium in indomethacin. Indomethacin has previ ously been reported to decrease antioxidant enzymes sod. Delayed healing of acetic acidinduced gastric ulcers in rats by. The present study aimed to investigate the antiulcerogenic activity of lzd on indomethacin ind induced duodenal ulcer in rats. Ficus exasperata against indomethacininduced gastric ulcer in rats.
Antiulcer activity methods indomethacin induced gastric ulcer albino rats of either sex weighing between 150175gm were housed in group of six in standard laboratory housing condition prior to experimentation. Furthermore, the poor gastric ulcers observed at dose 30mgkg and the very severe gastric ulcers at 50mgkg may be explained by the fact that usually, dosage determines effects. Protective roles of spondias mombin and ficus exasperata article pdf available in toxicology reports 51 january 2015 with 399 reads. Gastroprotective and antioxidant esects of opipramol on. Quercetin is considered to be an antioxidant with healing effects on many experimental toxic injuries. Gastroprotective and antioxidant effects of montelukast on. Group 2 indomethacin, rats were given oral administration of indomethacin at a concentration of 15 mgkgbody weight0. Protective effect of mirtazapine on indomethacininduced. Mechanisms underlying gastroprotective effect of paeonol.
Garlic, in its natural plant state, has a great history in. Lizhongtang lzt is a wellknown chinese herbal formulation first described in one of traditional chinese medicine tcm scriptures, treatise on fe. The rats were divided into four groups of seven animals in group as follows. In this paper, the gastroprotective effect of usnic acid ua isolated from usnea longissima was investigated in the indomethacininduced gastric ulcers in rats at doses of 25, 50, 100 and 200 mgkg body weight. In the present study, we found that 1 montelukast, lansoprazole, famotidine, and ranitidine all reduced the development of indomethacininduced gastric damage, with this reduction occurring. Nebivolol prevents indomethacininduced gastric ulcer in rats dois.
Traditional chinese medicine lizhongtang accelerates the. Ulceration was induced by a single oral administration of indomethacin 30. Mucosal injury characterized by, discontinuity in the mucosa d, lymphocyte infiltration arrows and erosions r in the epithelium e and lamina propria lp, hemorrhage h can be seen in. Antiulcerative effect of dexmedetomidine on indomethacin. Antioxidants free fulltext gastroprotective and anti. Liver and kidney function test, stomach malondialdehyde mda as oxidant marker and superoxidedismutase sod and total. Fruit pulp extract on indomethacininduced gastric ulcer in albino. Curative effect of hydrotalcite on indomethacin induced gastric injury. Research article the protective effect of testosterone on. Medicinalherbal extracts containing phytoconstituents have significant antiulcer activities in in vivo experiments on animal models, compared to reference drugs. Peptic ulcer diseases are common and are induced by many factors, including stress, smoking, and ingestion of nonsteroidal antiinflammatory drugs. Our results suggest that treatment with the stem bark extract of p. Ulcer indices and damage were elevated significantly in gastric tissues of diabetic compared with nondiabetic rats.
Nevertheless, gastric ulcers were present in all the groups treated with indomethacin. The gastric mucosa is continuously exposed to various agents like food condiments, spices, alcohol, acids and. Nebivolol prevents indomethacininduced gastric ulcer in rats nahla e. Protective roles of spondias mombin and ficus exasperata. While only a rat among the rats given 30mgkg indomethacin showed mild form of ulcer, all the rats given 40mgkg. Gastroprotective effect of vanillin on indomethacininduced gastric. Antioxidant activity of carica papaya seed extracts on.
Animals were randomly divided into six groups 10 rats each as follows. Peptic ulcer was induced in all the rats using indomethacin at 50mgkgbw single dose and the level of total endogenous anti oxidants were significantly p0. The present study was conducted to investigate the possible therapeutic effects of pinocembrin on indomethacin induced gastric ulcer model in rats. The parameters assessed were ph and acid concentration of gastric contents, and gastric ulcer index. Antiulcerogenic activity of lizhong decoction on duodenal. The evaluation of barringtonia asiatica on indomethacin. Antiulcer and hematological properties of virgin coconut.
Subcutaneous sc injections of indomethacin induce a severe enteropathy in rats that resembles human crohns disease. We reported that the daily administration of cortisone, aspirin, or indomethacin to rats with this ulcer for 1. Pdf gastroprotective effect of vanillin on indomethacin. Antiulcer and hematological properties of virgin coconut oil vco against indomethacininduced gastric ulcer in experimental rats joshua onyeagoziri okafor, parker elijah joshua and chimere young ukegbu 1department of biochemistry, university of nigeria, nsukka, nigeria. Nonsteroidal antiinflammatory drugs nsaids such as. Nsaids drugs use in pain management have been linked with ulcer and employed in several animal experiments, but the ulcer dose has been conflicting. The mean ulcer areas in rats given only indomethacin and only ibuprofen. Gastric ulcer is still the most prevalent irritant illness among the gastrointestinal diseases.
Indomethacin, opipramol, ranitidine and thiopental sodium were obtained from deva holdingturkey, novartisturkey, fakoturkey and ie ulagayturkey respectively. Protective effect of vitamin e on indomethacin induced gastric ulcers. They were usually fasted for a period of 2439 hours, allowing free excess to. After 6 hours of indomethacin administration, rats were. The protective effect of testosterone on indomethacin induced gastric ulcer in female sprague dawley rats u. Pdf protective effects of naringin in indomethacininduced. Each rat to receive nebivolol and omeprazole was given the agent orally by gavage daily for 10 days prior to induction of ulcer by oral dosing with indo. Esect of opipramol on indomethacininduced gastric ulcer in rats the antiulcer activities of diserent doses of opipramol were investigated in an indomethacininduced ulcer model in. Protective effects of naringin in indomethacininduced gastric ulcer. Delayed healing of acetic acidinduced gastric ulcers in. To confirm the curative effect of hydrotalcite against indomethacin induced gastric injury, gastric damage was induced by oral administration with a single dose of 30 mgkg indomethacin, and then different drugs or vehicle was treated by oral gavage for 3 days. The objective of present study is to investigate antiulcer activity of artocarpus heterophyllus lam. An acetic acid ulcer induced in the rat stomach is a chronic gastric ulcer model that gradu ally diminishes in size and depth until 4 wk after the ulceration, but persists for up to 250 days 4,5.
Animals either pretreated with pinocembrin 50mgkg for 3 days before ulcer induction with one single dose of indomethacin 48 mgkg orally or posttreated with pinocembrin 50mgkg3 days and 50mg. Twentyeight wistaralbino male rats were used in this study. Pdf upregulation of collagenase1 and 3 in indomethacin. Forty male albino rats were used in this study, divided into four groups control, pomegranate, peptic ulcer and treated groups.
Protective pathways and antisecretory mechanism article pdf available march 2017 with 389 reads how we. Effect of thyroid hormones on the healing of indomethacin induced gastric ulcers at days 3 a, c and e and 7 b, d and f after ulcer induction. Gastroprotective and antioxidant effects of opipramol on indomethacin induced ulcers in rats article pdf. We designed two experiments to study the preventive and curative effects of hydrotalcite on nsaidsrelated gastric injury in rats and to investigate the relationship between the protective and curative. Severity of gastric ulcers induced by indomethacin in mice is decreased by giving.
Thyroid hormones increase stomach goblet cell numbers and. Pdf protective effects of naringin in indomethacin. The effects of the aqueous stem bark extract was dose and duration dependent and this may justify its trial as an antiulcerogenic agent. Department of physiology, college of medicine, university of ibadan, ibadan, nigeria. Indomethacininduced gastric antral ulcers in hamsters.
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